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Huberman describes lithium's therapeutic mechanisms as suppressing brain inflammation and providing neuroprotection against excitotoxicity. He links long-term bipolar disorder to atrophy of neural circuits responsible for interoception.
Norman Farb says the default mode network automates patterns in life, making our brain a prediction machine that prioritizes efficiency over effortful processing.
Farb identifies a neural trade-off: the default mode network’s efficiency creates massive blind spots to possibilities outside our learned habits, hindering our ability to change.
Norman Farb’s neuroimaging study found depression was linked to deactivation of brain regions that process bodily sensations, not increased activity in the default mode network.
Farg argues that suppressing bodily sensations during sadness creates a feedback loop: the brain ruminates without new sensory input, perpetuating the negative state.
Norman Farb describes a tale of two brain partners: the front brain’s model-making network versus the back brain’s sensory regions open to chaotic, changing reality.